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In this study of adults with obesity without type 2 diabetes, tirzepatide produced an average body weight reduction of 20.2% over 72 weeks compared to 13.7% with semaglutide with average absolute weight loss of approximately 50 lbs versus 33 lbs

Melanotan 2 has legitimate effects but remains unregulated, carries contamination risks due to grey-market sourcing, and its use for cosmetic purposes is not currently supported by large-scale safety trials

In many patients, it was also found effective for RLS and has since been approved by the FDA

Retatrutide (LY3437943) is a novel incretin mimetic also created by Eli Lilly and studied for its potential in weight loss [10, 11]